Life-Threatening Respiratory Melancholy Inform patients on the risk of life-threatening respiratory despair, which include information the risk is greatest when starting up PERCOCET or when the dosage is enhanced, Which it could possibly come about even at encouraged dosages.

Accidental ingestion of oxycodone and acetaminophen tablets, Primarily by young children, may result in respiratory despair and death as a result of an overdose of oxycodone and acetaminophen tablets.

Because oxycodone is known being considerably excreted from the kidney, its clearance may perhaps reduce in patients with renal impairment. Initiate therapy with a lower than usual dosage of oxycodone hydrochloride and acetaminophen tablets and titrate carefully.

Convey to your physician if you are pregnant or approach to become pregnant. For those who take oxycodone often during your pregnancy, your little one might working experience life-threatening withdrawal symptoms after beginning.

Pregnant or intending to become pregnant. Prolonged use of oxycodone and acetaminophen tablets during pregnancy can cause withdrawal symptoms in your new child infant that can be life-threatening if not acknowledged and handled.

Adrenal insufficiency: Situations of adrenal insufficiency have been reported with opioid use, far more often adhering to higher than a person month of use.

Oral Contraceptives Boost in glucuronidation leading to elevated plasma clearance and a decreased half-life of acetaminophen.

Your physician or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you start your treatment with oxycodone and each time you fill your prescription.

Oxycodone produces respiratory depression by direct action on brain stem respiratory facilities. The respiratory despair entails a reduction from the responsiveness from the brain stem respiratory centers to both equally increases in carbon dioxide tension and electrical stimulation.

The precise mechanism in the analgesic action is unidentified. Nonetheless, distinct CNS opioid receptors for endogenous compounds with opioid-like action have been identified throughout the brain and spinal wire and so are imagined to Perform a role within the analgesic effects of this drug.

Serotonin syndrome: Circumstances of serotonin syndrome, a potentially life-threatening issue, have been described during concomitant utilization of opioids with serotonergic drugs.

Hire other supportive actions (like oxygen and vasopressors) inside the administration of circulatory shock and pulmonary edema as indicated. Cardiac arrest or arrhythmias would require Highly developed life-assist approaches.

Keep an eye on these kinds of patients closely, especially when initiating and titrating oxycodone and acetaminophen tablets and when oxycodone and acetaminophen tablets are provided concomitantly with other drugs that depress respiration [see WARNINGS; LIFE THREATENING RESPIRATORY DEPRESSION]. Alternatively, consider the use of percocet and xanax combination non-opioid analgesics in these patients.

you should know that this medication may possibly make you drowsy. Never travel a car, operate large equipment, or be involved in any other maybe dangerous activities till you know how this medication impacts you.